Elysia rufescens - natural products

March 10, 2002
From: Bill Rudman

Some time ago Lucas Cervera inquired about published results from research on E. rufescens. I just came across these references.

• Hamann, M.T. & Scheuer, P.J. (1993). Kahalalide F, a Bioactive Depsipeptide from the Sacoglossan Mollusk Elysia rufescens and the Green Alga Bryopsis sp.. J. Am. Chem. Soc.,115: 5825-5826
• Hamann, M.T., Otto, C.S., Scheuer, P.J., Dunbar, D.C (1996) Kahalalides: Bioactive Peptides from A Marine Mollusk Elysia rufescens and Its Algal Diet Bryopsis sp. J. Org. Chem., 61: 6594-6600.

Researchers at the University of Hawaii have been studying Elysia rufescens which feeds on Bryopsis sp.. It elaborates a series of depsipeptides ranging from a C31 tripeptide to a C75 tridecapeptide, kahalalide F(2). They have discovered that Kahalalide F has promising antitumor and antiviral activity. The new compound is active against solid tumors of the lung and colon and is present, in low concentration, in both Elysia and Bryopsis sp..

Bill Rudman

Rudman, W.B., 2002 (Mar 10) Elysia rufescens - natural products. [Message in] Sea Slug Forum. Australian Museum, Sydney. Available from http://www.seaslugforum.net/find/6392

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Elysia rufescens

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